|
|
lithocholic_acid + NAD+ <=> 3-oxo-5beta-cholan-24-oic_acid + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.52
3alpha-hydroxycholanate dehydrogenase (NAD+)
|
–
–
–
–
–
|
M
|
| |
BRENDA:
BR29316
KEGG:
R04139
MetaCyc:
1.1.1.52-RXN
SABIO-RK:
3860
|
|
|
|
lithocholic_acid + NADP+ <=> 3-oxo-5beta-cholan-24-oic_acid + NADPH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.392
3alpha-hydroxycholanate dehydrogenase (NADP+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
–
–
–
–
|
M
|
| |
BRENDA:
BR51558
KEGG:
R11145
MetaCyc:
RXN-12689
SABIO-RK:
10578
|
|
|
|
lithocholoyl-CoA + cholic_acid <=> choloyl-CoA + lithocholic_acid
|
2.8.3.25
bile acid CoA-transferase
|
–
|
|
| |
BRENDA:
BR51766
KEGG:
R11539
MetaCyc:
RXN-17406
|
|
|
|
lithocholic_acid + reduced_flavodoxin + O2 <=> hyodeoxycholic_acid + flavin + H2O
|
1.14.14.57
taurochenodeoxycholate 6alpha-hydroxylase
|
–
|
|
| |
BRENDA:
BR48566
KEGG:
R07206
|
|
|
|
lithocholic_acid + reduced_flavodoxin + O2 <=> 6beta-hydroxylithocholate + flavin + H2O
|
1.14.14.138
lithocholate 6beta-hydroxylase
|
–
|
|
| |
BRENDA:
BR48569
KEGG:
R07203
|
|
|
|
chenodeoxycholic_acid + FADH2 <=> lithocholic_acid + FAD + H2O
|
not assigned
|
–
|
|
| |
KEGG:
R03978
|
|
|
|
lithocholic_acid + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 6beta-hydroxylithocholate + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.138
lithocholate 6beta-hydroxylase
|
–
|
|
| |
MetaCyc:
1.14.13.94-RXN
|
|
|
|
lithocholic_acid + reduced_[NADPH-hemoprotein_reductase] + O2 <=> hyodeoxycholic_acid + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.57
taurochenodeoxycholate 6alpha-hydroxylase
|
–
|
|
| |
MetaCyc:
RXN-7977
|
|
|
|
lithocholoyl-CoA + allocholate <=> lithocholic_acid + allocholoyl-CoA
|
2.8.3.25
bile acid CoA-transferase
|
–
|
|
| |
BRENDA:
BS437674
|
|
|
|
UDP-glucuronate + lithocholic_acid <=> UDP + lithocholic_acid_3-beta-D-glucuronoside + lithocholic_acid_24-beta-D-glucuronoside
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS436046
|
|
|
|
lithocholic_acid <=> 3-oxo-5beta-cholan-24-oic_acid + NADH + H+
|
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
|
–
|
|
| |
BRENDA:
BS439715
|
|
|
|
taurolithocholate + H2O <=> lithocholic_acid + taurine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
| |
BRENDA:
BS448984
|
|
|
|
lithocholic_acid + NADP+ <=> Dehydrolithocholic_acid + NADPH
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
|
–
|
|
| |
BRENDA:
BS230620
|
|
|
|
lithocholic_acid + NADPH + H+ <=> ursodeoxycholate + NADP+
|
1.1.1.159
7alpha-hydroxysteroid dehydrogenase
1.1.1.201
7beta-hydroxysteroid dehydrogenase (NADP+)
|
–
–
|
|
| |
BRENDA:
BS438390
|
|
|
|
3''-phosphoadenylyl-sulfate + lithocholic_acid <=> adenosine_3'',5''-bisphosphate + lithocholate_3-sulfate
|
2.8.2.14
bile-salt sulfotransferase
2.8.2.34
glycochenodeoxycholate sulfotransferase
|
–
–
|
|
| |
BRENDA:
BS360178
|
|
|
|
glycolithocholic_acid + H2O <=> lithocholic_acid + glycine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
| |
BRENDA:
BS448657
|
|
|
|
ATP + H2O + lithocholic_acid <=> ADP + phosphate + lithocholic_acid
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
| |
BRENDA:
BS445069
|
|
|
|
ATP + lithocholic_acid + CoA <=> AMP + diphosphate + lithocholoyl-CoA
|
6.2.1.7
cholate---CoA ligase
|
–
|
|
| |
BRENDA:
BS347
|
|
|
|
lithocholoyl-CoA + chenodeoxycholic_acid <=> lithocholic_acid + chenodeoxycholoyl-CoA
|
2.8.3.25
bile acid CoA-transferase
|
–
|
|
| |
BRENDA:
BS437675
|
|
